Rola diety MIND w profilaktyce i wspomaganiu leczenia chorób neurodegeneracyjnych

Aleksandra Stepaniuk; Agnieszka Kluz; Alicja Kucharska

doi:10.57655/EXLIBRIS_1_2025_2

Published : 2025-09-25

Vol. 28 No. 1 (2025)

The role of the MIND diet in preventing and supporting the treatment of neurodegenerative diseases

Aleksandra Stepaniuk

https://orcid.org/0009-0006-4489-3551

Agnieszka Kluz

https://orcid.org/0009-0006-7427-5818

Alicja Kucharska

https://orcid.org/0000-0002-6738-2088

DOI: https://doi.org/10.57655/EXLIBRIS_1_2025_2

Abstract

The increase in the number of older adults in society is leading to a rise in the prevalence of neurodegenerative diseases, posing new challenges for the health care system and preventive health care. This article discusses the role of the MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet in preventing and treating these diseases. The article outlines the mechanisms of neurodegeneration and the effects of aging on brain function. It describes recent studies on the impact of the MIND diet, which combines elements of the Mediterranean and DASH diets, on the risk of Alzheimer's disease, Parkinson's disease, and dementia. It also identifies the components of the MIND diet that may support cognitive health and delay neurodegenerative changes. The available data suggests that the MIND diet may significantly support brain function and quality of life in older adults, but more research is needed on its long-term effects.

Keywords:

neurodegenerative diseases, cognitive function, MIND diet, primary and secondary prevention

Details

References

Statistics

Authors

Download files

PDF - pełny tekst artykułu (Język Polski)

Citation rules

Stepaniuk, A., Kluz, A., & Kucharska, A. (2025). The role of the MIND diet in preventing and supporting the treatment of neurodegenerative diseases. Exlibris Social Gerontology Journal, 28(1), 33–48. https://doi.org/10.57655/EXLIBRIS_1_2025_2

Altmetric indicators

Cited by / Share

Licence

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

References

Afzal, O., Dalhat, M. H., Altamimi, A. S. A., Rasool, R., Alzarea, S. I., Almalki, W. H., Murtaza, B. N., Iftikhar, S., Nadeem, S., Nadeem, M. S., & Kazmi, I. (2022). Green tea catechins attenuate neurodegenerative diseases and cognitive deficits. Molecules, 27(21), 7604.

Agarwal, P., Leurgans, S. E., Agrawal, S., Aggarwal, N. T., Cherian, L. J., James, B. D., Dhana, K., Barnes, L. L., Bennett, D. A, Schneider, J. A. (2023). Association of Mediterranean-DASH intervention for neurodegenerative delay and Mediterranean diets with Alzheimer disease pathology. Neurology, 100(22), e2259-e2268.

Agarwal, P., Wang, Y., Buchman, A. S., Holland, T. M., Bennett, D. A. & Morris M. C. (2018). MIND diet associated with reduced incidence and delayed progression of parkinsonism in old age. Journal of Nutrition, Health & Aging, 22(10), 1211–1215.

Azam, S., Haque, M. E., Balakrishnan, R., Kim, I.-S., Choi, D. K. (2021). The ageing brain: molecular and cellular basis of neurodegeneration. Frontiers in Cell and Developmental Biology, 9, 683459.

Baker, L. D., Snyder, H. M., Espeland, M. A., Whitmer, R. A., Kivipelto, M., Woolard, N., Katula, J., Papp, K. V., Ventrelle, J., Graef, S., Hill, M. A., Rushing, S., Spell, J., Lovato, L., Felton, D., Williams, B. J., Ghadimi Nouran, M., Raman, R., Ngandu, T., Solomon, A., Wilmoth, S., Cleveland, M. L., Williamson, J. D., Lambert, K. L., Tomaszewski Farias, S., Day, C. E., Tangney, C. C., Gitelman, D. R., Matongo, O., Reynolds, T., Pavlik, V. N., Yu, M. M., Alexander, A. S., Elbein, R., McDonald, A. M., Salloway, S., Wing, R. R., Antkowiak, S., Morris, M. C., Carrillo, M. C.; U.S. POINTER Study Group (2024). Study design and methods. U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER). Alzheimer's & Dementia, 20(2), 769–782.

Boumenna, T., Scott, T. M., Lee, J. S., Zhang, X., Kriebel, D., Tucker, K. L., Palacios, N. (2022). MIND diet and cognitive function in Puerto Rican older adults. Journal of Gerontology: Biological Sciences and Medical Sciences, 77(3), 605–613.

Cai, Y., Song, W., Li, J. et al. (2022). The landscape of aging. China Life Sciences, 65, 2354–2454.

Cao, L., Tan, L., Wang, H. F., Jiang, T., Zhu, X. C., Lu, H., Tan, M. S., & Yu, J. T. (2016). Dietary patterns and risk of dementia. A systematic review and meta-analysis of cohort studies. Molecular neurobiology, 53(9), 6144–6154.

Chen, X., Maguire, B., Brodaty, H., & O’Leary, F. (2019). Dietary Patterns and Cognitive Health in Older Adults. A Systematic Review. Journal of Alzheimer's disease: JAD, 67(2), 583–619.

Cook, D. J., Mulrow, C. D., & Haynes, R. B. (1997). Systematic reviews. Synthesis of best evidence for clinical decisions. Annals of Internal Medicine, 126(5), 376–380.

de Crom, T. O. E., Mooldijk, S. S., Ikram, M. K., Ikram, M. A., Voortman, T. (2022). MIND diet and the risk of dementia. A population-based study. Alzheimer's Research & Therapy, 14(1), 8.

Dhana, K., James, B. D., Agarwal, P., Aggarwal, N. T., Cherian, L. J., Leurgans, S. E., Barnes, L. L., Bennett, D. A., Schneider, J. A. (2021). MIND Diet, common brain pathologies, and cognition in community-dwelling older adults. Journal of Alzheimer's Disease, 83(2), 683–692.

Fox, D. J., Park, S. J., Mischley, L. K. (2022). Comparison of associations between MIND and Mediterranean diet scores with patient-reported outcomes in Parkinson’s disease. Nutrients, 14(23), 5185.

Gahtani, R. M., Shoaib, S., Hani, U., Jayachithra, R., Alomary, M. N., Chauhan, W., Jahan, R., Tufail, S., Ansari, M. A. (2024). Combating Parkinson's disease with plant-derived polyphenols. Targeting oxidative stress and neuroinflammation. Neurochemistry International, 178, 105798.

Galiniak, S., Aebisher, D., Bartusik-Aebisher, D. (2019). Health benefits of resveratrol administration. Acta Biochimica Polonica, 66(1), 13–21.

García-Aguilar, A., Palomino, O., Benito, M., Guillén, C. (2021). Dietary polyphenols in metabolic and neurodegenerative diseases. Molecular targets in autophagy and biological effects. Antioxidants (Basel), 10(2), 142.

GUS. (2021). Sytuacja osób starszych w Polsce w 2020 r. Główny Urząd Statystyczny, Urząd Statystyczny w Białymstoku.

Herrero, M. T., Morelli, M. (2017). Multiple mechanisms of neurodegeneration and progression. Progress in Neurobiology, 155, 1.

Holthaus, T. A., Kashi, M., Cannavale, C. N., Edwards, C. G., Aguiñaga, S., Walk, A. D. M., Burd, N. A., Holscher, H. D., Khan, N. A. (2022). MIND Dietary Pattern adherence is selectively associated with cognitive processing speed in middle-aged adults. Journal of Nutrition, 152(12), 2941–2949.

Huang, L., Tao, Y., Chen, H., Chen, X., Shen, J., Zhao, C., Xu, X., He, M., Zhu, D., Zhang, R., Yang, M., Zheng, Y., & Yuan, C. (2023). Mediterranean-dietary approaches to stop hypertension intervention for neurodegenerative delay (MIND) diet and cognitive function and its decline. A prospective study and meta-analysis of cohort studies. The American Journal of Clinical Nutrition, 118(1), 174–182

Huang, L., Zhao, C., Gao, M., Tao, Y., Chen, X., Chen, H., Li, F., Zheng, Y., Lu, M., Ma, Y., Rong, S., Yuan, C. (2024). Associations of vegetable and fruit intake with cognitive function and its decline. Two longitudinal studies. The Journal of Nutrition, Health and Aging, 28(6), 100223.

Jiang, Y. W., Sheng, L. T., Feng, L., Pan, A., Koh, W. P. (2021). Consumption of dietary nuts in midlife and risk of cognitive impairment in late life. The Singapore Chinese Health Study. Age and Ageing, 50, 1215–1221.

Kaniewska, N., Kupiec, J. (2021). Znaczenie bioaktywnych związków żywności w rozwoju i profilaktyce chorób neurodegeneracyjnych. W: Babicz, M., Kropiwiec-Domańska, K. (2021). Wybrane zagadnienia z zakresu bromatologii (ss. 52–58). Uniwersytet Przyrodniczy w Lublinie.

Kivipelto, M., Solomon, A., Ahtiluoto, S., Ngandu, T., Lehtisalo, J., Antikainen, R., Bäckman, L., Hänninen, T., Jula, A., Laatikainen, T., Lindström, J., Mangialasche, F., Nissinen, A., Paajanen, T., Pajala, S., Peltonen, M., Rauramaa, R., Stigsdotter-Neely, A., Strandberg, T., Tuomilehto, J., Soininen, H. (2013). The Finnish geriatric intervention study to prevent cognitive impairment and disability (FINGER). Study design and progress. Alzheimer's & Dementia, 9, 657–665.

Kurczyńska, A., Ślusarczyk, K. (2020). Żywieniowe czynniki i kontrowersje w zapobieganiu demencji. Zeszyty Naukowe Państwowej Wyższej Szkoły Zawodowej im. Witelona w Legnicy, 4(37), 69–89.

Metcalfe-Roach, A., Yu, A. C., Golz, E., Cirstea, M., Sundvick, K., Kliger, D., Foulger, L. H., Mackenzie, M., Finlay, B. B., Appel-Cresswell, S. (2021). MIND and Mediterranean diets associated with later onset of Parkinson’s disease. Movement Disorders, 36(4), 977–984.

Mirzaei, F., Agbaria, L., Bhatnagar, K., Sirimanne, N., A’amar, N. O., Jindal, V., Thilagendra, A. G., Raba, F. T. (2024). Coffee and Alzheimer's disease. Progress in Brain Research, 289, 21–55.

Morris, M. C., Tangney, C. C., Wang, Y., Sacks, F. M., Bennett, D. A., Aggarwal, N. T. (2015). MIND diet associated with reduced incidence of Alzheimer's disease. Alzheimer's & Dementia, 11(9), 1007–1014.

Morris, M. C., Wang, Y., Barnes, L. L., Bennett, D. A., Dawson-Hughes, B., Booth, S. L. (2018). Nutrients and bioactives in green leafy vegetables and cognitive decline. Prospective study. Neurology, 90(3), e214–e222.

Outeiro, T. F., Brocardo, P. S., Gelain, D. P. (2024). Aging and neurodegeneration. From molecular mechanisms to therapeutic interventions. Journal of Neurochemistry, 168(8), 1423–1425.

Przedborski, S., Vila, M., Jackson-Lewis, V. (2003). Neurodegeneration. What is it, and where are we? Journal of Clinical Investigation, 111(1), 3-10.

Raeis-Abdollahi, E., Raise-Abdullahi, P., Rashidy-Pour, A., Meamar, M., Askari, H. (2024). Coffee's protective mechanisms against neurodegeneration. Progress in Brain Research, 288, 167–200.

Rajaram, S., Valls-Pedret, C., Cofán, M., Sabaté, J., Serra-Mir, M., Pérez-Heras, A. M., Arechiga, A., Casaroli-Marano, R. P., Alforja, S., Sala-Vila, A., Doménech, M., Roth, I., Freitas-Simoes, T. M., Calvo, C., López-Illamola, A., Haddad, E., Bitok, E., Kazzi, N., Huey, L., Fan, J., Ros, E. (2017). The walnuts and healthy aging study (WAHA). Protocol for a nutritional intervention trial with walnuts on brain aging. Frontiers in Aging Neuroscience, 8, 333.

Rajaram, S., Jones, J., Lee, G. J. (2019). Plant-based dietary patterns, plant foods, and age-related cognitive decline. Advances in Nutrition, 10(Suppl. 4), 422–436.

Rodwell, V. W., Bender, D. A, Botham, K. M, Kenelly, P. J, Weil, A. P. (2021). Biochemia Harpera, wydanie VII. PZWL Wydawnictwo Lekarskie.

Ros, E., Singh, A., O'Keefe, J. H. (2021). Nuts. Natural pleiotropic nutraceuticals. Nutrients, 13(9), 3269.

Sukhera, J. (2022). Narrative reviews in medical education. Key steps for researchers. Journal of Graduate Medical Education, 14(4), 418–419.

Szczudlik, A., Barcikowska-Kotowicz, M., Gabryelewicz, T. (2016). Sytuacja osób chorych na chorobę Alzheimera w Polsce. Raport RPO (ss. 24–33). Biuro Rzecznika Praw Obywatelskich.

United Nations, Department of Economic and Social Affairs, Population Division (2019). World Population Prospects 2019, Volume II: Demographic Profiles (ST/ESA/SER.A/427), https://www.un.org/development/desa/pd/sites/www.un.org.development.desa.pd/files/un_2019_wpp_vol2_demographic-profiles.pdf

Wang, H., Abbas, K. M., Abbasifard, M., Abbasi-Kangevari, M., Abbastabar, H., Abd-Allah, F., ... & Damiani, G. (2020). Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019. The Lancet, 396(10258), 1160-1203.