Activities related to research and development work are of great importance to the growth and development of enterprises, in particular those from the advanced technology sector, which operate at the interface between science and economy. A significant part of research and development work is carried out in the form of design work, and one of the factors proving the success thereof is a well-selected and competent project team and the competences of R&D project managers, who play a key role in the process of project task implementation. The aim of the article is to identify the competences of an R&D project manager based on the example of a selected high-tech enterprise. Despite numerous scientific studies verifying key managerial competences, there is a lack of research on the competences of R&D project managers. Data has been gathered via a single cross-sectional survey with a structured questionnaire based on a group of 67 employees of PREVAC Sp. z o.o., a company in the high-tech sector. Exploratory factor analysis has been used to analyse the empirical results of the study. The results of the study indicate that social and intrapersonal competences are the most desirable among the key competences of the R&D project manager, while the remaining ones complement this model.